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Monday, August 25, 2025

Synergy Pharmaceuticals


Synergy Pharmaceuticals – Product Catalog (A–Z)

  • Trulance → Generic: plecanatide (guanylate cyclase-C agonist) → Indication:

    • Chronic idiopathic constipation (CIC) in adults

    • Irritable bowel syndrome with constipation (IBS-C)
      → Dose: Oral tablets 3 mg once daily

  • Dolcanatide (pipeline) → Generic: dolcanatide (next-gen guanylate cyclase-C agonist, analog of uroguanylin) → Indication: Inflammatory bowel disease (ulcerative colitis, IBS-C) — investigational, Phase II before bankruptcy → Dose: Oral tablets (trial stage)

  • SP-333 (developmental code name for dolcanatide) → Same molecule as above, tested in ulcerative colitis and opioid-induced constipation (OIC).


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