Definition
Tonsillitis is an acute or chronic inflammation of the palatine tonsils, most often due to viral or bacterial infection, causing sore throat and pharyngeal discomfort.
Causes
Viral (most common)
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Adenovirus
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Rhinovirus
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Epstein–Barr virus (EBV – infectious mononucleosis)
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Influenza virus
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Parainfluenza virus
Bacterial
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Group A β-haemolytic streptococcus (Streptococcus pyogenes) – most common bacterial cause
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Group C or G streptococci
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Neisseria gonorrhoeae (rare, sexually acquired)
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Corynebacterium diphtheriae (rare, in unvaccinated)
Risk Factors
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Age 5–15 years (most common)
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Close contact in schools, dormitories
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Exposure to individuals with pharyngitis
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Immunosuppression
Clinical Features
Symptoms
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Sore throat, odynophagia (pain on swallowing)
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Fever
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Malaise, fatigue
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Earache (referred pain)
Signs
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Enlarged, erythematous tonsils ± exudates (white/yellow patches)
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Tender anterior cervical lymphadenopathy
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Halitosis
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Palatal petechiae (in streptococcal infection)
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In EBV: hepatosplenomegaly, diffuse lymphadenopathy
Complications
Suppurative
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Peritonsillar abscess (quinsy)
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Retropharyngeal abscess
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Otitis media, sinusitis
Non-suppurative (post-streptococcal)
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Rheumatic fever
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Post-streptococcal glomerulonephritis
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Scarlet fever
Diagnosis
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Clinical evaluation
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Centor or FeverPAIN criteria to assess probability of Group A streptococcus (GAS) infection
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Throat swab with rapid antigen detection test (RADT) or culture (if GAS suspected)
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Monospot test / EBV serology if infectious mononucleosis suspected
Treatment
General measures
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Rest, hydration, warm saline gargles
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Analgesia/antipyretics: paracetamol or ibuprofen
Antibiotics (for confirmed/suspected bacterial tonsillitis with high Centor/FeverPAIN score)
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Phenoxymethylpenicillin (penicillin V):
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Adults: 500 mg orally every 6–12 hours for 10 days
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Children: 12.5–25 mg/kg/dose every 6–12 hours (max 500 mg/dose) for 10 days
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Amoxicillin: not recommended if EBV suspected (causes rash)
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Penicillin allergy: clarithromycin or azithromycin for 5 days
Recurrent/severe cases
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Consider tonsillectomy if ≥7 episodes/year, ≥5/year for 2 years, or ≥3/year for 3 years
Prognosis
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Most cases resolve in 3–7 days with supportive care
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Antibiotics shorten duration slightly in bacterial cases and reduce complications
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