Shire plc

Shire plc – Product Catalog (A–Z)

Adderall / Adderall XR → Generic: mixed amphetamine salts → Indication: ADHD, narcolepsy → Dose: Tabs 5–30 mg; XR capsules 5–30 mg

Advate → Generic: antihemophilic factor (recombinant, Factor VIII) → Indication: Hemophilia A → Dose: IV infusion vials 250–3000 IU

Adynovate → Generic: antihemophilic factor [recombinant], PEGylated → Indication: Hemophilia A (extended half-life) → Dose: IV infusion vials 250–3000 IU

Agrylin → Generic: anagrelide hydrochloride → Indication: Essential thrombocythemia (to reduce platelet count) → Dose: Caps 0.5 mg, 1 mg

Aralast NP → Generic: alpha1-proteinase inhibitor (human) → Indication: Alpha-1 antitrypsin deficiency → Dose: IV infusion vials 500–1000 mg

Baxalta legacy brands (post-2016 acquisition) → Examples: Vonvendi, Feiba, Gammagard (see hematology below)

Buccolam → Generic: midazolam (oromucosal solution) → Indication: Acute seizures in children → Dose: Prefilled syringes 2.5, 5, 7.5, 10 mg

Cuvitru → Generic: immune globulin SC (human) → Indication: Primary immunodeficiency → Dose: SC infusion, 20% solution vials

Cinryze → Generic: C1 esterase inhibitor (human) → Indication: Hereditary angioedema (HAE) prophylaxis → Dose: IV infusion 500–2100 units

Elaprase → Generic: idursulfase (enzyme replacement) → Indication: Hunter syndrome (MPS II) → Dose: IV infusion 0.5 mg/mL

Elvanse / Vyvanse → Generic: lisdexamfetamine dimesylate → Indication: ADHD, binge eating disorder (U.S.) → Dose: Caps 20–70 mg; chewables

Firazyr → Generic: icatibant acetate → Indication: Acute attacks of hereditary angioedema (HAE) → Dose: Prefilled syringe 30 mg SC

Gammagard → Generic: immune globulin IV (human) → Indication: Primary immunodeficiency, CIDP → Dose: IV infusion 5% & 10% solutions

Hydrea → Generic: hydroxyurea → Indication: Sickle cell disease, certain leukemias → Dose: Capsules 500 mg

Idelvion → Generic: coagulation Factor IX (recombinant), albumin fusion protein (rFIXFc) → Indication: Hemophilia B → Dose: IV infusion vials 250–3000 IU

Intuniv → Generic: guanfacine ER → Indication: ADHD (non-stimulant) → Dose: ER tabs 1–4 mg

Kalbitor → Generic: ecallantide → Indication: Acute HAE attacks → Dose: SC injection 30 mg

Lialda → Generic: mesalamine (delayed/extended release) → Indication: Ulcerative colitis → Dose: ER tablets 1.2 g

Natpara → Generic: parathyroid hormone (PTH 1–84) → Indication: Hypoparathyroidism → Dose: SC injection cartridge 25–100 mcg (suspended in 2020 for cartridge defect)

Oncaspar → Generic: pegaspargase → Indication: Acute lymphoblastic leukemia (ALL) → Dose: IV/IM injection vials 750 IU/m²

Plenadren → Generic: hydrocortisone (dual-release) → Indication: Adrenal insufficiency → Dose: Modified-release tablets 5–30 mg

Replagal → Generic: agalsidase alfa (enzyme replacement) → Indication: Fabry disease → Dose: IV infusion 0.2 mg/kg q2w

Resolor → Generic: prucalopride → Indication: Chronic idiopathic constipation → Dose: Tabs 1–2 mg

Siklos → Generic: hydroxyurea (pediatric formulation) → Indication: Sickle cell anemia → Dose: Scored tablets 100 mg, 1000 mg

Tretten → Generic: coagulation Factor XIII A-subunit (recombinant) → Indication: Congenital FXIII deficiency → Dose: IV infusion 250–1250 IU vials

Vpriv → Generic: velaglucerase alfa → Indication: Gaucher disease type 1 → Dose: IV infusion 60 U/kg q2w

Vyvanse (Elvanse in EU/JP) → Generic: lisdexamfetamine dimesylate → Indication: ADHD, binge eating disorder → Dose: Caps 20–70 mg

Xagrid → Generic: anagrelide hydrochloride → Indication: Essential thrombocythemia → Dose: Caps 0.5–1 mg