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Monday, August 25, 2025

Sage Therapeutics


Sage Therapeutics – Product Catalog (A–Z)

  • Zulresso → Generic: brexanolone (IV allopregnanolone) → Indication: Postpartum depression (PPD) in adults → Dose: Continuous IV infusion 60 hours, administered in certified healthcare facility (REMS program)

  • Zurzuvae → Generic: zuranolone (oral neuroactive steroid, GABA-A receptor positive allosteric modulator) → Indication: Major depressive disorder (MDD) & postpartum depression (PPD) → Dose: Capsules 50 mg once daily for 14 days

  • SAGE-718 (pipeline) → Generic: novel NMDA receptor positive allosteric modulator → Indication: Cognitive impairment in Huntington’s disease, Parkinson’s disease, Alzheimer’s disease → Dose: Oral (various doses under trial)

  • SAGE-324 (pipeline) → Generic: next-generation GABA-A receptor modulator → Indication: Essential tremor, epilepsy → Dose: Oral formulation, phase 2 trials

  • SAGE-689 (pipeline) → Generic: IV neuroactive steroid → Indication: Acute GABAergic disorders (status epilepticus, ICU sedation adjunct) → Dose: IV infusion, early-stage development


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