BioDelivery Sciences International

BioDelivery Sciences International products

• Belbuca®

  • Generic: buprenorphine buccal film

  • Indication: severe, persistent pain requiring long-term opioid therapy

  • Dose: 75–900 mcg every 12 hours; titrated as needed

• Bunavail® (discontinued in U.S.)

  • Generic: buprenorphine + naloxone buccal film

  • Indication: opioid use disorder treatment/maintenance

  • Dose: 2.1/0.3 mg – 12.6/2.1 mg once daily; target 8.4/1.4 mg once daily

• Elyxyb®

  • Generic: celecoxib oral solution

  • Indication: acute migraine treatment in adults

  • Dose: 120 mg once as needed (max 120 mg per 24 hours); 60 mg if hepatic impairment or poor CYP2C9 metabolizer

• Onsolis®

  • Generic: fentanyl buccal soluble film

  • Indication: breakthrough cancer pain in opioid-tolerant adults

  • Dose: start 200 mcg; titrate up to 1,200 mcg; limit 1 film per episode, ≤4 episodes per day

• Symproic®

• Generic: naldemedine tablets

• Indication: opioid-induced constipation in adults with chronic non-cancer pain

• Dose: 0.2 mg once daily