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Wednesday, August 27, 2025

Aeterna Zentaris


Aeterna Zentaris — A to Z Product Catalog

Marketed Product

  • Macrilen® (macimorelin acetate)
    • Generic: Macimorelin, an oral ghrelin agonist
    • Indication: Diagnostic test for adult growth hormone deficiency (AGHD)
    • Dose/Form: Single oral dose (~1.0 mg/kg) as part of a growth hormone stimulation test

Investigational and Historical Pipeline

  • AIM Biologicals
    • Type: Autoimmunity-modifying fusion proteins (HLA-G based)
    • Indication: Potential treatment for neuromyelitis optica spectrum disorder (NMOSD) and Parkinson’s disease
    • Dose/Form: Preclinical stage

  • Avenanthramides (natural oat-derived compounds)
    • Type: Natural anti-inflammatory polyphenols
    • Indication: Systemic inflammation, skin irritation, and related chronic conditions
    • Dose/Form: Oral formulations (liquid or superfine powder)—phase 1/2 clinical evaluation ongoing

  • Oat Beta Glucan
    • Type: Natural oat-derived polysaccharide
    • Indication: Skin barrier function, cholesterol regulation, gut health
    • Dose/Form: Nutraceutical/cosmeceutical ingredient

  • Zoptarelin Doxorubicin (AEZS-108)
    • Generic: Doxorubicin conjugated to an LHRH peptide
    • Indication: Targeted treatment of endometrial cancer (LHRH-receptor positive tumors)
    • Dose/Form: Intravenous administration; development discontinued in 2017


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