Aeterna Zentaris

Aeterna Zentaris — A to Z Product Catalog

Marketed Product

• Macrilen® (macimorelin acetate)
  • Generic: Macimorelin, an oral ghrelin agonist
  • Indication: Diagnostic test for adult growth hormone deficiency (AGHD)
  • Dose/Form: Single oral dose (~1.0 mg/kg) as part of a growth hormone stimulation test

Investigational and Historical Pipeline

• AIM Biologicals
  • Type: Autoimmunity-modifying fusion proteins (HLA-G based)
  • Indication: Potential treatment for neuromyelitis optica spectrum disorder (NMOSD) and Parkinson’s disease
  • Dose/Form: Preclinical stage

• Avenanthramides (natural oat-derived compounds)
  • Type: Natural anti-inflammatory polyphenols
  • Indication: Systemic inflammation, skin irritation, and related chronic conditions
  • Dose/Form: Oral formulations (liquid or superfine powder)—phase 1/2 clinical evaluation ongoing

• Oat Beta Glucan
  • Type: Natural oat-derived polysaccharide
  • Indication: Skin barrier function, cholesterol regulation, gut health
  • Dose/Form: Nutraceutical/cosmeceutical ingredient

• Zoptarelin Doxorubicin (AEZS-108)
  • Generic: Doxorubicin conjugated to an LHRH peptide
  • Indication: Targeted treatment of endometrial cancer (LHRH-receptor positive tumors)
  • Dose/Form: Intravenous administration; development discontinued in 2017

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